EA Sports—of all places, given its adherence to simulation style now—released a Mortal Kombat-esque football game with Mutant League Football in 1993. The game was fun then and quickly spawned a cult-like following that's still going strong. 

By all accounts, Mutant League Football had a Madden-like feel to it with a strong play-calling screen and the expected overhead camera. But the violence, characters, post-apocalyptic setting and ability to bribe officials, to name a few details, were overboard and a fun take on the genre.